Macrophages

Subset annotations

UMAP projections show macrophage subsets


Heatmaps show mean expression of gene lists described by Culemann et al. Replicates are shown separately for each macrophage subset.

CCR2_ARG1_infiltrating



CCR2_IL1B_infiltrating



CX3CR1_lining



RELMa_interstitial



AQP1_interstitial




CHIKV+ cells


Differential expression

Heatmap shows top upregulated genes associated with inflammatory disease for CHIKV vs mock-infected macrophages


UMAP projections show examples of upregulated genes for mock vs CHIKV-infected macrophages


Top genes upregulated in CHIKV-infected mice are shown below for each macrophage subset.

AQP1_interstitial


CX3CR1_lining


infiltrating


RELMa_interstitial


unassigned


Simmons et al. 

SLAMF7_stim



SLAMF7_high



arthritis



T cells

Genes upregulated in T cells from CHIKV vs mock-infected mice are shown below. All CD4+ or CD8+ T cells were grouped together.


Ifng expression is shown below for each T cell subset